abstract：BACKGROUND AND AIM:Although several meta-analyses suggested that sequential therapy (SQT) is superior to standard triple therapy (STT) for the eradication of Helicobacter pylori, these results were mainly based on the studies from Italy. The aim of this study was to assess the efficacy of 10-day SQT for H. pylori infec...

journal_title：Journal of gastroenterology and hepatology

authors： Yoon H,Lee DH,Kim N,Park YS,Shin CM,Kang KK,Oh DH,Jang DK,Chung JW

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND AIM:T-cell responses against hepatitis C are believed to be critical in achieving both natural and treatment-induced clearance. However, rapid clearance of antigen with early treatment of primary infection may result in reduced or poorly sustained cellular immunity. This study longitudinally examined Th1...

journal_title：Journal of gastroenterology and hepatology

authors： Flynn JK,Dore GJ,Hellard M,Yeung B,Rawlinson WD,White PA,Kaldor JM,Lloyd AR,Ffrench RA,ATAHC Study Group.

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND AIM:Liver fibrosis is an established determinant of prognosis and therapy in chronic hepatitis B (CHB). The role of fibroscan in assessing fibrosis in CHB remains unclear. Present study was designed to correlate fibroscan with liver biopsy and determine whether fibroscan can avoid liver biopsy in patient...

journal_title：Journal of gastroenterology and hepatology

authors： Goyal R,Mallick SR,Mahanta M,Kedia S,Shalimar,Dhingra R,Sharma H,Das P,Datta Gupta S,Panda S,Acharya SK

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND AIM:At the same time that Helicobacter pylori prevalence is declining in Western countries, immigrants from developing countries with high H. pylori prevalence have settled in Western urban areas. Actual epidemiological data on H. pylori in a migrant community may help in realizing a more selective appro...

journal_title：Journal of gastroenterology and hepatology

authors： den Hollander WJ,Holster IL,den Hoed CM,van Deurzen F,van Vuuren AJ,Jaddoe VW,Hofman A,Perez Perez GI,Blaser MJ,Moll HA,Kuipers EJ

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND AIMS:The role of serum quantitative hepatitis B surface antigen (qHBsAg) in identifying hepatitis B virus (HBV) carriers with significant fibrosis is unknown. This study aims to evaluate the diagnostic value of qHBsAg for hepatic fibrosis in hepatitis B e antigen (HBeAg)-positive HBV carriers. METHODS:C...

journal_title：Journal of gastroenterology and hepatology

authors： Xun YH,Zang GQ,Guo JC,Yu XL,Liu H,Xiang J,Liu J,Shi JP

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Gilbert's syndrome is a common familial hyperbilirubinemia that may reduce the risk of various age-related diseases because of the antioxidant properties of bilirubin. We conducted a large cohort study using The Health Improvement Network primary care database and compared all-cause mortality rates ...

journal_title：Journal of gastroenterology and hepatology

authors： Horsfall LJ,Nazareth I,Pereira SP,Petersen I

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND AND AIM:By array-comparative genomic hybridization, we demonstrated cyclin E as one of seven genes associated with hepatocellular carcinoma (HCC) development in Ku70 DNA repair-deficient mice. We therefore explored the hypothesis that during hepatocarcinogenesis, cyclin E kinase can overcome the inhibitory e...

journal_title：Journal of gastroenterology and hepatology

authors： Pok S,Wen V,Shackel N,Alsop A,Pyakurel P,Fahrer A,Farrell GC,Teoh NC

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND AIM:Hyperphosphatemia has been implicated in the development and treatment of various cancers. However, whether it can be used as a direct prognostic marker of colorectal cancer (CRC) has remained unexplored. Given new insights into the importance of hyperphosphatemia in CRC, we sought to evaluate the as...

journal_title：Journal of gastroenterology and hepatology

authors： Ye Z,Palazzo JP,Lin L,Lai Y,Guiles F,Myers RE,Han J,Xing J,Yang H

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND AIM:Recently, microRNAs (miRNA) have been linked to the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH). First transcribed as pri-miRNA, these molecules are further processed by a complex of endonuclear and cytosolic RNA binding molecu...

journal_title：Journal of gastroenterology and hepatology

authors： Sharma H,Estep M,Birerdinc A,Afendy A,Moazzez A,Elariny H,Goodman Z,Chandhoke V,Baranova A,Younossi ZM

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is a clinical entity where there is a potential for reversibility of hepatic dysfunction once the acute hepatic insult resolves. The portal and systemic hemodynamics in ACLF patients to study its relevance in determining the clinical outcomes was studied. METHO...

journal_title：Journal of gastroenterology and hepatology

authors： Garg H,Kumar A,Garg V,Kumar M,Kumar R,Sharma BC,Sarin SK

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Belching is a common disorder with undetermined pathogenesis. With the combined multichannel intraluminal impedance pH monitoring, two different models of belching have been defined: gastric belching (GB) and supragastric belching (SB). The aim of this study was to assess whether SB was associated w...

journal_title：Journal of gastroenterology and hepatology

authors： Li J,Xiao Y,Peng S,Lin J,Chen M

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND AIM:Barrett's esophagus (BE) is a premalignant condition to esophageal adenocarcinoma. It is currently not clear whether cigarette smoking increases the risk of developing BE, and no meta-analysis has been performed on the topic. We conducted a systematic review and meta-analysis, providing a quantitativ...

journal_title：Journal of gastroenterology and hepatology

authors： Andrici J,Cox MR,Eslick GD

更新日期：2013-08-01 00:00:00

abstract：:Alcohol use is a leading cause of preventable morbidity and mortality worldwide, with much of its negative impact as the result of alcoholic liver disease (ALD). ALD is a broad term that encompasses a spectrum of phenotypes ranging from simple steatosis to steatohepatitis, progressive fibrosis, cirrhosis, and hepatoce...

journal_title：Journal of gastroenterology and hepatology

authors： Orman ES,Odena G,Bataller R

更新日期：2013-08-01 00:00:00

abstract：:The prevalence of patients presenting with fatty liver disease (FLD) in China has approximately doubled over the past two decades. At present, FLD, which is typically diagnosed by imaging, is highly prevalent (≈ 27% urban population) in China and is mainly related to obesity and metabolic syndrome (MetS). However, the...

journal_title：Journal of gastroenterology and hepatology

authors： Fan JG

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Positron emission tomography with computed tomography (PET/CT) has been used to detect metastasis in the diagnosis of esophageal adenocarcinoma (EAC). However, the utility of PET/CT to assess primary tumor for endoscopic resectability and prognosis in early EAC remains unclear. We conducted a retros...

journal_title：Journal of gastroenterology and hepatology

authors： Sun G,Tian J,Gorospe EC,Johnson GB,Hunt CH,Lutzke LS,Leggett CL,Iyer PG,Wang KK

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND AIM:Liver transplantation remains the best option for treating type-1 hepatorenal syndrome (HRS1). The aim of this retrospective study was to determine whether the molecular adsorbent recirculation system (MARS) can improve renal function in HRS1 patients. METHODS:Thirty-two patients with chronic liver ...

journal_title：Journal of gastroenterology and hepatology

authors： Lavayssière L,Kallab S,Cardeau-Desangles I,Nogier MB,Cointault O,Barange K,Muscari F,Rostaing L,Kamar N

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND AIM:Transforming growth factor-β (TGF-β) has been shown to play a central role in the promotion of cell motility, but its functional mechanism has remained unclear. With the aim of investigating the diagnostic and treatment modalities for patients with hepatocellular carcinoma (HCC), the signaling pathwa...

journal_title：Journal of gastroenterology and hepatology

authors： Sato M,Matsuda Y,Wakai T,Kubota M,Osawa M,Fujimaki S,Sanpei A,Takamura M,Yamagiwa S,Aoyagi Y

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Liver biopsy is the gold standard test to determine the grade of fibrosis, but there are associated problems. Because gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid is secreted partially in hepatocytes and bile, it is possible that ethoxybenzyl-magnetic resonance imaging (EOB-MRI) corre...

journal_title：Journal of gastroenterology and hepatology

authors： Nojiri S,Kusakabe A,Fujiwara K,Shinkai N,Matsuura K,Iio E,Miyaki T,Joh T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Although capsule endoscopy (CE) is widely used as a first-line diagnostic modality for obscure gastrointestinal bleeding (OGIB), the rebleeding rate after negative CE varies according to different studies. We tried to elucidate the outcomes after negative CE for OGIB and to determine the risk factor...

journal_title：Journal of gastroenterology and hepatology

authors： Kim JB,Ye BD,Song Y,Yang DH,Jung KW,Kim KJ,Byeon JS,Myung SJ,Yang SK,Kim JH

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Sepsis is an important complication and cause of morbidity and mortality in acute pancreatitis (AP). The source of sepsis may be infected pancreatic and peripancreatic collections and/or necrosis or extrapancreatic including infections in the bloodstream or respiratory and urinary tracts. We studied...

journal_title：Journal of gastroenterology and hepatology

authors： Rao C,Bhasin DK,Rana SS,Gupta R,Gautam V,Singh K

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND AND AIM:Intestinal failure (IF) is a rare but devastating complication of Crohn's disease (CD). The clinical and surgical factors that predispose to IF are poorly understood. The aim of this study was to define clinical factors that predispose to IF. METHODS:A retrospective case-control study was performed ...

journal_title：Journal of gastroenterology and hepatology

authors： Gearry RB,Kamm MA,Hart AL,Bassett P,Gabe SM,Nightingale JM

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND AND AIM:Epidemiology of Helicobacter pylori infection has regional variation. Effect of eradication of H. pylori on symptoms of functional dyspepsia is uncertain, and the data in Asian scenario are scanty. The study aimed to see H. pylori positivity rate in patients of functional dyspepsia and the effect of ...

journal_title：Journal of gastroenterology and hepatology

authors： Sodhi JS,Javid G,Zargar SA,Tufail S,Shah A,Khan BA,Yattoo GN,Gulzar GM,Khan MA,Lone MI,Saif Ru,Parveen S,Shoukat A

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Dysbiosis is thought to be relevant to the etiology and pathogenesis of Crohn's disease (CD). In this study, we investigated the abundance of Faecalibacterium prausnitzii, as well as Bilophila wadsworthia, in the gut microbiota of Japanese CD patients. METHODS:Forty-seven CD patients and 20 healthy...

journal_title：Journal of gastroenterology and hepatology

authors： Fujimoto T,Imaeda H,Takahashi K,Kasumi E,Bamba S,Fujiyama Y,Andoh A

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND AIMS:In the gastric mucosa of portal hypertensive rats, adaptive cytoprotection against ethanol-induced damage is impaired. The aim of this study was to determine relation between impaired adaptive cytoprotection and oxidative stress. METHODS:Portal hypertension was produced in male Sprague-Dawley rats ...

journal_title：Journal of gastroenterology and hepatology

authors： Kawano Y,Ohta M,Eguchi H,Iwashita Y,Inomata M,Kitano S

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND AIM:Although regulatory T cells (Treg) and interleukin-17-producing CD4 T cells (Th17) have been demonstrated to play opposing roles in inflammation-associated diseases, their frequency and balance in different stages of hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) remain unknown...

journal_title：Journal of gastroenterology and hepatology

authors： Zhang GL,Xie DY,Lin BL,Xie C,Ye YN,Peng L,Zhang SQ,Zhang YF,Lai Q,Zhu JY,Zhang Y,Huang YS,Hu ZX,Gao ZL

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Advanced glycation end products (AGEs) are nonenzymatic modifications of proteins by reducing sugars. These compounds accumulate in a number of chronic disease states, contributing to tissue injury via several mechanisms, including activation of the receptor for advanced glycation end products (RAGE...

journal_title：Journal of gastroenterology and hepatology

authors： Goodwin M,Herath C,Jia Z,Leung C,Coughlan MT,Forbes J,Angus P

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND AIM:Helicobacter pylori cagA can be classified into mainly two types (East-Asian-type and Western-type cagA) according to the repeat regions located in the 3' region. Recent studies showed that the Western-type cagA in strains from Okinawa, Japan formed a different cluster (J-Western-type cagA subtype). ...

journal_title：Journal of gastroenterology and hepatology

authors： Matsuo Y,Shiota S,Matsunari O,Suzuki R,Watada M,Binh TT,Kinjo N,Kinjo F,Yamaoka Y

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND AIM:Common endoscopic findings in stomachs with Helicobacter pylori infections include antral nodularity, thickened gastric folds, and visible submucosal vessels. These findings are suggestive but not diagnostic of H. pylori infection. Magnifying endoscopy can reveal more precisely the abnormal mucosal p...

journal_title：Journal of gastroenterology and hepatology

authors： Cho JH,Chang YW,Jang JY,Shim JJ,Lee CK,Dong SH,Kim HJ,Kim BH,Lee TH,Cho JY

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND AIM:Pepsinogen (PG) method is widely used to identify high risk groups of gastric cancer. It is very useful before Helicobacter pylori eradication, but after eradication the method becomes useless because the PGI, PGII, PGI/II ratios change. Therefore, we aimed to identify a high risk group for gastric c...

journal_title：Journal of gastroenterology and hepatology

authors： Haneda M,Kato M,Ishigaki S,Suzuki M,Takahashi M,Nakagawa M,Ono S,Mori Y,Mabe K,Nakagawa S,Kudo T,Shimizu Y,Asaka M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND AIM:Endoscopic screening for esophageal varices (EVs) is expensive and invasive. Besides traditional noninvasive markers, we explore additional candidate markers including portal hypertension serum marker-soluble CD136 (sCD163) and genetic variants of splanchnic vasodilatation and revascularization pathw...

journal_title：Journal of gastroenterology and hepatology

authors： Yang YY,Hou MC,Lin MW,Chen PH,Liao WC,Chu CJ,Lin HC

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND AIM:Hepatic fibrosis is a worldwide healthy burden associated with significant morbidity and mortality. It is caused by a variety of chronic liver injuries. There is currently no effective treatment for liver fibrosis. In this report, we tested an imidazolium salt, 1,3-diisopropylimidazolium tetrafluorob...

journal_title：Journal of gastroenterology and hepatology

authors： Ding Z,Zhuo L

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND AIM:Chronic alcoholic liver disease is associated with hepatic insulin resistance, dysregulated lipid metabolism with increased toxic lipid (ceramide) accumulation, lipid peroxidation, and oxidative and endoplasmic reticulum (ER) stress. Peroxisome-proliferator activated receptor (PPAR) agonists are insu...

journal_title：Journal of gastroenterology and hepatology

authors： Ramirez T,Tong M,Chen WC,Nguyen QG,Wands JR,de la Monte SM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND AIM:Development of hepatic cirrhosis involves oxidative stress, inflammation, hepatic stellate cells (HSC)s activation and fibrosis. On the other hand, quercetin, a natural flavonoid is a potent antioxidant and activator of superoxide dismutase and catalase. The aim was to determinate the effect of querc...

journal_title：Journal of gastroenterology and hepatology

authors： Hernández-Ortega LD,Alcántar-Díaz BE,Ruiz-Corro LA,Sandoval-Rodriguez A,Bueno-Topete M,Armendariz-Borunda J,Salazar-Montes AM

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND AIM:The most effective schedule of proton pump inhibitor (PPI) administration and the optimal timing of endoscopy in acute peptic ulcer bleeding remain uncertain. The aim of this study was to determine the most efficient PPI regimen and optimal timing of endoscopy. METHODS:  Consecutive patients with su...

journal_title：Journal of gastroenterology and hepatology

authors： Liu N,Liu L,Zhang H,Gyawali PC,Zhang D,Yao L,Yang Y,Wu K,Ding J,Fan D

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND AIM:Little information is available about the antiviral efficacy of lamivudine (LAM) and entecavir (ETV) in patients with hepatitis B virus (HBV)-related advanced hepatocellular carcinoma (HCC). Thus, we compared the antiviral efficacy of LAM and ETV in these patients. METHODS:The medical records of 134...

journal_title：Journal of gastroenterology and hepatology

authors： Shin HS,Kim SU,Park JY,Kim DY,Han KH,Chon CY,Baatarkhuu O,Ahn SH

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND AIM:Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) of unknown etiology. We aimed to identify the etiological agent of CD using a molecular cloning strategy that was particularly focused on identifying agents causing immune abnormalities and infectious agents. METHODS:We constructed a...

journal_title：Journal of gastroenterology and hepatology

authors： Iizuka M,Nakagomi O,Nanjo H,Chiba M,Fukushima T,Sugita A,Sagara S,Horie Y,Watanabe S

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND AIM:Although larger biopsies sample had been recommended for the study of non-invasive liver fibrosis assessment, few studies with larger biopsies for transient elastography (TE) detecting liver fibrosis had been reported. The present study tries to re-evaluate the performance of TE for detecting advance...

journal_title：Journal of gastroenterology and hepatology

authors： Chen YP,Liang XE,Zhang Q,Peng J,Zhu YF,Wen WQ,Hou JL

更新日期：2012-07-01 00:00:00

abstract：:Ulcerative colitis (UC) and Crohn's disease (CD) comprise the idiopathic inflammatory bowel diseases (IBD) of the gut. The etiology of IBD is poorly understood, but an autoimmune disturbance has been suggested to play an important role in this incurable disease. Extracorporeal leukocytapheresis (CAP) is an additional ...

journal_title：Journal of gastroenterology and hepatology

authors： Fukunaga K,Matsumoto T

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND AND AIM:Contrast harmonic endoscopic ultrasound (CH-EUS) was recently introduced to clinical practice; its reproducibility among endosonographers is unknown. Our aim was to assess the interobserver agreement (IA) in CH-EUS. METHODS:Fifteen endosonographers (eight experienced and seven non-experienced) from ...

journal_title：Journal of gastroenterology and hepatology

authors： Fusaroli P,Kypraios D,Mancino MG,Spada A,Benini MC,Bianchi M,Bocus P,De Angelis C,De Luca L,Fabbri C,Grillo A,Marzioni M,Reggio D,Togliani T,Zanarini S,Caletti G

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND AND AIM:HFE mutations, a common cause of hereditary hemochromatosis (HH), are reportedly associated with hepatic iron overload, severe liver fibrosis, and good response to interferon treatment in European patients with chronic hepatitis C (CHC). HH shows ethnicity-based differences and little is known about ...

journal_title：Journal of gastroenterology and hepatology

authors： Ishizu Y,Katano Y,Honda T,Hayashi K,Ishigami M,Itoh A,Hirooka Y,Nakano I,Goto H

更新日期：2012-06-01 00:00:00